A Subsequent Study of Visualized Sequence Comparison Based on Ten Types of Viruses

Dawei Li
Rockefeller University

Lin He
Shanghai Jiao Tong University

Abstract

A New Kind of Science, by Stephen Wolfram, is attracting great attention worldwide. The real revolution in science or life can start from the point that simple rules are able to produce highly complex behaviors. It will shape the current theory of deoxyribonucleic acid (DNA) sequence analysis. Visualized analysis of sequence comparison in the current study as well as the approach of sequence homology in our previous study support that the visualized approach is suitable for the studies of general organisms. We analyzed ten types of viruses using the visualized approach. Some similar characteristics were found between the messenger ribonucleic acid (mRNA) sequence of avian infectious bronchitis virus and the genome sequence of SARS virus, which supported the significance of the behaviors implicated in the nested structures. In contrast with the traditional methods based on sequence comparison, Wolfram's approach pays more attention to the interaction of power regulations among the adjacent bases. It has some advantages for the analysis of different sequences on either individual base pair or whole genome level, including the overall and itemized analyses of magnification of the tiny changes on DNA sequences. The approach is a good categorization tool based on its high divergence and sensitivity. The results may be fundamental but interesting for subsequent studies.